SOLUTION: The ledger entries in the image, such as "Act. of Calvin Howell" (an early Old Plymouth resident), "Cotton Bales," "River Freight - To Mobile," and the "October 1842" date, combined with the "Lowndes County" location and the depiction of a significant river, point to the historic (and now lost) river port of Old Plymouth.
The area circled in red on the faint map beneath the ledger text uses a traditional 19th-century symbol (a rectangle with small crosses) to denote Plymouth Cemetery.